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October 11, 2003

Fragile chromosomes, cancer and paradigm shift

This press release from the University of California at San Diego summarizes some major change in the conception of genetic rearrangement, no longer does "random breakage theory" hold, rather, there are "fragile regions" that are likened to "genetic earthquakes" (am the only one that feels the rhetoric reminds of some sort of molecular saltationism???). It has implications for both evolutionary theory and practical changes in our conception of cancers and the role of chromosomal rearrangements in their development and origin. Here is the abstract for the paper in June put out by some bioinformaticists who compared mouse and human genomes, and a recent follow-up that vindicates the original researchers.

Posted by razib at 01:26 PM