http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/ Genetics Tue, 03 Apr 2018 05:20:42 +0000 hourly 1 https://wordpress.org/?v=3.8.27 http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26755 Sun, 05 Nov 2006 21:03:30 +0000 #comment-26755 nice site 
http://www.flowers-shop.org/

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26756 Sun, 05 Nov 2006 21:02:54 +0000 #comment-26756 good site 
http://www.pokkers.org/

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26757 Sun, 05 Nov 2006 21:01:29 +0000 #comment-26757 best site 
http://www.pregnancy.net.in/

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26758 Mon, 31 Jul 2006 03:03:45 +0000 #comment-26758 i expect this kind of data before too long 
 
no doubt

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26759 Sun, 30 Jul 2006 13:34:44 +0000 #comment-26759 a whole-genome look at methylation would give us a better picture of how important this is in humans. i expect this kind of data before too long.

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26760 Sun, 30 Jul 2006 12:32:03 +0000 #comment-26760 So identical DNA sequences might actually be different genes, especially in the case of quantitative traits. 
 
you mean different alleles? but yeah, it’s intriguing stuff. if epigenetic inheritance is widespread, it would be pretty revolutionary, though if epimutations are stable and thus inherited in a mendelian fashion, it wouldn’t change a whole lot in terms of theory– evolution is substrate-neutral, after all.  
 
but in practice, when looking for genes involved in complex traits, epigenetics adds another layer of complexity.  
 
I think linkage studies should be robust to causal mutations being stable epimutations, but I’m not so sure about association studies. a reason for irreprodicible association results? (thinking out loud here, but I’m not so sure. I imagine there’s some correlation between genetic variation and epigenetic variation) 
 
but there are only a few examples of epigenetic inheritance now. no one knows how big a role it’s going to play.

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26761 Sun, 30 Jul 2006 10:55:21 +0000 #comment-26761 So identical DNA sequences might actually be different genes, especially in the case of quantitative traits. 
 
Should we be more excited about this?

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26762 Sat, 29 Jul 2006 21:14:55 +0000 #comment-26762 Given that my green tomato pickle recipe is one of my leading search engine hit generators, I would say that there is commercial value in a tomato that does not ripen. If the effect had been discovered in another plant, I would guess we are not far from being able to apply this understanding to develop a GM green tomato. Kind of silly that it wil be much easier to market a “naturally occuring” one.

]]> http://www.gnxp.com/new/2006/07/28/mendelian-epigenetics/#comment-26763 Fri, 28 Jul 2006 15:47:23 +0000 #comment-26763 i don’t remember all the details, but this reminds me of the Arabidopsis superman/kryptonite story 
 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11898023&dopt=Abstract

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