Stabilized, not activated

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The Daily Transcript reports on a PNAS study showing that transcription occurs in bursts. Transcription factors (regulators of when a gene is “on” or “off”) are often characterized as ‘activators’ or repressors. The paper suggests activators may instead be stabilizers. Genes are always flipping back and forth between different levels of on and off states and when transcription factors bind they can hold one state steady. When upregulation happens a gene isn’t ‘turned on’, it is just kept on. He’s got a nice little def. of transcription on the left there. You are eventually gonna need to know what transcription and translation are. Might as well be now.


  1. turns certain old conceptual frameworks upside down 
    i am a little antiquated tho

  2. This is an interesting paper. I will have to read through the details of the mathematical model later.