MECP2 and brain structure

Posted by on August 20, 2009; This entry is filed under Uncategorized.
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ScienceDaily, Genetic Variations Linked To Brain Size. The write-up seems a bit garbled to me, so probably best to read the paper, A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations, when it is live on the PNAS site.

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6 Comments

  1. Dominic August 21st, 2009 at 7:32 am

    You know, when PNAS finally gets there stuff together, it would be nice if they had a functional site that actually has the papers reported. 
     
    I’m sure they’ll get it up since I’ve already complained to them (again) about their site’s deficiencies. But PNAS is a clusterf-ck.

  2. pconroy August 21st, 2009 at 1:15 pm

    Can anyone tell me which SNP(s) are involved, and what are the derived values for the alleles – as I understand there may be a link to autism also, which is interesting – thanks.

  3. Dominic August 24th, 2009 at 11:12 am

    Yeah, I got a pre-release of the paper which, by the way, is still not live on the website and the SNP is rs2239464. 
     
    It’ll be interesting to see if this replicates. PNAS can s-ck my p-nats. You can email me if you want the pdf.

  4. Rich Stoner August 25th, 2009 at 6:08 pm

    I’ve been waiting for PNAS to get this online for over a week now – glad to see I’m not the only one.

  5. razib August 25th, 2009 at 9:39 pm

    pnas does this all the time. i used to complain about it, but no point….

  6. pconroy August 26th, 2009 at 8:32 am

    Here is a graph of the gene MECP2, SNP rs223946 distribution worldwide. 
     
    It seems that the Basque have the highest values for the derived form (rs2239464=G), followed by the Sardinians and Orcadians. I also have the derived form…

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