Posts Tagged ‘mutations’

Robustness and fragility in neural development

So many things can go wrong in the development of the human brain it is amazing that it ever goes right. The fact that it usually does – that the majority of people do not suffer from a neurodevelopmental disorder – is due to the property engineers call robustness. This property has important implications for […]

De novo mutations in autism

A trio of papers in this week’s Nature identifies mutations causing autism in four new genes, demonstrate the importance of de novo mutations in the etiology of this disorder and suggest that there may be 1,000 or more genes in which high-risk, autism-causing mutations can occur. These studies provide an explanation for what seems like […]

Complex interactions among epilepsy genes

A debate has been raging over the last few years over the nature of the genetic architecture of so-called “complex” disorders. These are disorders – such as schizophrenia, epilepsy, type II diabetes and many others – which are clearly heritable across the population, but which do not show simple patterns of inheritance. A new study […]

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