Interesting paper out in JAMA, Coffee, CYP1A2 genotype, and risk of myocardial infarction: The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are “rapid” caffeine … Continue reading Genetics + coffee = death…or…not