This year at ASHG one of the most fascinating talks was Po-Ru Loh’s, where he reviewed the BOLT-REML method. It’s introduced in the paper, Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. As you likely know many diseases such as schizophrenia manifest as complex trait; that is, they’re basically quantitative … Continue reading A golden age of quantitative genomics here