Thursday, July 21, 2005

The BTNL2 Gene and Sarcoidosis Susceptibility in African Americans and Whites   posted by Razib @ 7/21/2005 12:04:00 AM


...Although rs2076530 was not associated with sarcoidosis in either African American sample, a three-locus haplotype that included rs2076530 was associated with sarcoidosis across all three study samples. Multivariable logistic regression analyses showed that BTNL2 effects are independent of human leukocyte antigen class II genes in whites but may interact antagonistically in African Americans. Our results underscore the complexity of genetic risk for sarcoidosis emanating from the MHC region.