There's been some talk about the dynamics of genome architecture on the comments, so I thought I'd point to Mike Lynch's The origins of eukaryotic gene structure (Open Access). The paper is a reduction of the major themes presented in the book of the similar name. This is of course only Lynch's view; but by making a positive argument he sketches out implicitly objections and counterpoints to his contentions. You can find many more of his papers on his website; his ideas on genome architecture go way back (at least in terms of the "post-genomic era").

Labels: Genetics