Monday, March 10, 2008
About a year ago a paper came out, Low Levels of Genetic Divergence across Geographically and Linguistically Diverse Populations from India. The authors used Asian Indian groups from the United States, ergo, the caste/class representativeness is not is very typical. Additionally, there is a strong skew to Gujaratis since this group represents 1/2 of American Asian Indians. One could offer the reasonable opinion that the low amount of between population variance is simply a function of the fact that higher status groups across South Asia are not particularly differentiated from each other. I don't have a final opinion, but I would be moderately skeptical of this because I've seen enough work in the past suggesting that Brahmins, for example, are not particularly closely related to each across regions (and many of these regional Brahmin groups show strong evidence of gene flow with other local caste groups, though there usually there is some differentiation).
In any case, that's just a preface to the fact that a provisional paper has come out from the same group, Prevalence of common disease-associated variants in Asian Indians. If you're interested in the topic of the paper, all I have to say is that it seems that the major inference one might make is that more studies need to be done with Asian Indians because they likely have a whole lot of population-specific disease variants which aren't well known yet. Human biodiversity has some practical medical implications. But that's not what I want to focus on. In Table 4 they have some data on frequency of the minor frequency allele on SLC24A5, which in the case of South Asians is the ancestral variant. That is, the allele which is fixed in Africans and East Asians, and absent in Europeans, is the one shown in the table.
There's nothing that surprising here. I wouldn't take some of the frequencies as scripture; I suspect that some of these linguistic groups are not representative (the frequency for the Gujaratis I can believe since I've seen it elsewhere, while the northwestern groups are in line with the ones from the HGDP populations). It seems likely that a strong NW-SE cline on the variation of this gene exists just as it does on many genes in South Asia. There is data which shows that in Sri Lanka the frequency of the ancestral allele is 0.75 for Tamils, and 0.50 for Sinhalese. I wouldn't read too much into these data either; but I've seen results elsewhere which would imply that you shouldn't be surprised at seeing a ancestral allele frequency around ~0.25 for South Asians on SLC24A5. I know this is a provisional paper, and this might get yanked, but I want to point this out:
The MAF [minor allele frequency] for the SLC24A5 g.13242G>A polymorphism [the ancestral allele] (0.114) in the Indian population is closer to that of Caucasian European populations (0.000-0.020) than to that of East Asians (0.979-0.989) and Africans (0.730-0.980)...This is surprising given that, as a whole, people of Indian origin have darker skin tone compared to Europeans. The East Asian and African populations share a similarly high frequency of the minor allele of the SLC24A5 g.13242G>A SNP, which in itself is surprising as East Asians are typically of much lighter skin than Africans. It is also interesting that the t-test suggested a greater similarity in MAF between Indians and those of populations in the Americas (Puerto Rican, Mexican, and Amerindian), who are of a similar skin tone....
No shit it's surprising. We know that SLC24A5 polymorphism can account for about 1/3 of the skin color variation in South Asians. It isn't as if it doesn't affect skin color in this population due to some modifier locus. The frequencies of SLC24A5 alleles in Latin American populations is just a proxy for European and non-European admixture; the non-European groups in Latin America are Amerindians and Africans, both of whom tend to carry the ancestral variant.
In any case, contrary to the impressions of those of you who only know of South Asians from Bollywood, Indians are on average darker-skinned than Puerto Ricans or Mestizos. SLC24A5 has been under selection within the last 10,000 years. It explains 25-40% of the between group difference in complexion of Europeans and Africans (checked via an admixture study with African Americans). But there's no way I think that light skin was being selected in southern India within the last 10,000 years. Something else is going on....
Labels: human biodiversity