Saturday, June 24, 2006

Developmental cell biology of ASPM   posted by Razib @ 6/24/2006 01:06:00 PM

Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells

...Our results demonstrate that Aspm is crucial for maintaining a cleavage plane orientation that allows symmetric, proliferative divisions of NE cells during brain development. These data provide a cell biological explanation of the primary microcephaly observed in humans with mutations in ASPM, which also has implications for the evolution of mammalian brains.

Update: Previous commentary on ASPM.