Saturday, June 13, 2009

Mapping phenotypic variation in chickens   posted by p-ter @ 6/13/2009 10:05:00 PM

PLoS Genetics has a nice paper identifying copy-number polymorphism in the transcription factor SOX5 as the causal mutation leading to the pea-comb phenotype (the bottom panels on the right) in chickens. The mutation leads to more widespread expression of the gene at a particular developmental time point, which presumably represses comb formation.