Update on Boosting Intelligence Here's a summary of the important recent research on genetically engineered intelligent mice: 1) Mice with large brains are covered here. It's not clear yet whether the folds thus created mean smarter mice. 2) Modified NMDA receptors are the basis of Tsien's work on the Doogie Mouse 3) Modified calcineurin regulation is the basis for the Vanderbilt work here. 4) Modified nerve growth is the basis for the Northwestern work here. Thus, we have 3 (possibly 4 if the brain enlargement one stands up) independent routes to boosting mammalian intelligence. I find it amusing that obfuscators and doubters continue to insist that modifying human intelligence is "too hard" or "impossible". Ah, well, what would a supervillain like myself be without a foil?