Sunday, December 31, 2006

Human Genetics round-up   posted by agnostic @ 12/31/2006 12:19:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

The new issue of Human Genetics has three articles that may interest GNXP readers. A study on the genetics of height looked at two groups of normal Japanese males (i.e., no cases of Marfan Syndrome), one tall (+2 SD; N =219) and one average (+/- 1 SD; N = 209). A SNP in the FBN1 gene was significantly overrepresented in the tall group, and the number of copies was significantly positively correlated with height within each group too. The mutation doesn't result in an amino acid change.

A study on the genetics of skin color variation looked at loci from Europeans, Africans, and Chinese (HapMap and Perlegen data) and performed tests of Fst (a measure of within-group vs. between-group variation) and decay of haplotype homozygosity (a measure of positive selection similar to the integrated Haplotype Score statistic used in the Voight et al 2006 study). They largely confirmed previous findings, but they also discovered a new locus involved in skin color differences between Chinese and non-Chinese populations, DCT (p. 617, all square brackets mine):

The core SNP was chosen as the SNP within the DCT gene with the most extreme riEHH value [i.e., their measure of positive selection]. This SNP, rs2031526, has a riEHH value within the top 1.7% of the riEHH distribution and has Fst values within the top 0.6 and 0.3% of the Afr–Chn and Eur–Chn HapMap Fst distributions respectively (AC Fst = 0.718; EC Fst = 0.607). Figure 2 demonstrates that the derived A allele in the Chinese is found on a high frequency haplotype with long-range homozygosity, while the Europeans and Africans show substantial breakdown of homozygosity over the same physical distance on the high frequency, ancestral G allele haplotype. Similar results were obtained when other core SNPs with extreme riEHH values from the DCT gene were used (data not shown). Thus, the DCT gene harbors a signature of local positive selection in Chinese using both Fst and LRH-based tests [LRH = Long-Range Haplotype], and is therefore a potential candidate to account for the differences in skin pigmentation between the Chinese and other human populations.

So here we have yet another example of different populations converging on more or less the same phenotype (lightish skin) via somewhat different evolutionary genetic paths. UPDATE: Dienekes links to another new study of convergent evolution of skin color in Europeans and East Asians.

Lastly, a study on the make-up of neutral portions of the African-American genome examined how much Europeans and Africans have contributed. The gist, including numbers, is contained in the abstract. In brief, they found sex-biased gene flow: European male - African female pairings are primarily responsible for admixture, a pattern which the authors note is also common in Native American - European admixed populations in the Americas. And apropos of a recent query at Razib's ScienceBlog, here's what they found on the Native American contribution to African-Americans:

A small contribution from Native American and Asian populations to the founding of African Americans has previously been reported (Parra et al. 2001; Smith et al. 2004; Reiner et al. 2005). In those analyses, the genetic contribution from Native Americans and Asians in individuals is at most 2.6% and generally falls between 1 and 2%. Reiner et al. (2005) showed that there was a greater likelihood that the African American population descended from two populations (as opposed to one, three, or four) which was consistent with our own STRUCTURE analysis, where two populations fit the data best. These analyses showed that it was not necessary to include Native Americans and Asians in the founder populations. Our Y chromosome analysis also supported that there was little contribution from Native Americans since the predominant Y haplogroups found in Native Americans P(xR) were not observed in this sample of African Americans.


Gay sheep, forbidden science?   posted by Razib @ 12/31/2006 03:59:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Science told: hands off gay sheep:
Scientists are conducting experiments to change the sexuality of "gay" sheep in a programme that critics fear could pave the way for breeding out homosexuality in humans.


You can read the whole article yourself. Randall Parker has been saying for years that genetic engineering will accentuate human differences as parents will choose to invest in alternative enhancements with their finite dollars. The vectors may remain the same, but the magnitudes could increase, as religious parents breed super-religious offspring, secular parents start spawning born atheists, and what not. There is a pretty obvious and straightforward way for homosexuals to calm down their fears that straight parents will genetically engineer out their orientation (ergo, community): breed gay babies. If scientists can understand homosexuality well enough to "cure" it, then they could certainly turn fetuses gay.


2006 Darwin Awards   posted by dobeln @ 12/31/2006 01:23:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

So, they are here. Moral of story: Obey the laws of physics kids! With no further ado - the winners:

Hammer of Doom: A Brazil man tried to disassemble a missile by car, and by sledgehammer...

Copper Kite String: Precautions must be taken to avoid sudden electrocution...

High on Life: Four feet found protruding from a helium advertising balloon...

Score for Goliath: A mythical giant felled by a humble slingshot: a modern speargun versus an underwater leviathan...

Faithful flotation: a pastor who could literally walk on water...

Stubbed out: If a doctor advises that the one thing you must avoid is an open flame, most people ould not strike a match...

Star Wars: Luke vs. Darth Vader, with light sabres made from fluorescent tubes and gasoline...

And if you didn't win this year, you have all of 2007 to make a go for it! Happy new year!


Appendix: Darwin Awards 2006 Demographics:

Countries:
England - 3 winners
Florida - 3 winners
Gabon - 1 winner
Belize - 1 winner
Brazil - 1 winner

Average winner age: 29 years

Winner gender:
8 men
1 woman

Saturday, December 30, 2006

I'm brown dammit!   posted by Razib @ 12/30/2006 05:38:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

I was in a public place the other day and some small Arab-looking guy was talking really loudly in what sounded like Arabic on the phone. I was reading a book and eventually the guy was like, "Hey, do you speak Arabic?" I was like, "No." And he replied, "Do you speak Mexican?" And I replied, "Uh, no." So he goes on, "Where you from?" I reply, "My family is from Bangladesh." His response? "Is that India?" I say, "Kind of." "I was born in India. Abu Sabbas. You know Abu Sabbas?" I replied, "No." He continued, "It's north of Napali. You know Napali?" I didn't, but I smiled and nodded. "My father was working in India. I'm from Israel." Finally he left me alone.

Friday, December 29, 2006

Speech and motor feedback   posted by amnestic @ 12/29/2006 09:40:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

I am really enjoying Buzsaki's book. The chapter I'm in now is about perturbations of the intrinsic network activity of the nervous system. He examines some of the earliest developing examples of intrinsic neural activity: self-generated activities that help organize the retina to visual cortex mapping and the twitches and kicks of the developing fetus. He is building the point that a nervous system that cannot generate motor output cannot really perceive the world in a meaningful way.

"Only through movement can distances be measured and incorporated into our sensory scheme. For an immobile observer, direction, distance, and location of sensory information are incomprehensible and meaningless concepts."


At another level of analysis he notes that a baby's babbles are self-organized output that is then perturbed by parents via their reaction to babbles that chance upon parts of their own words. Perturbation can reshape the weights of the network and organize them in terms of experience.

It made me wonder about the FOXP2 story. There has been some debate about where exactly the deficit lies in the KE family, the family that has a heritable language disorder. Some have suggested that the main effect of FOXP2 loss is to reduce fine motor control of the face and jaw (and tongue?) that would allow for speech production. I wonder if this motor loss might propagate backwards to a more general loss of language functions. Buzsaki covers some studies in which developing rats are immobilized in one way or the other. The inability to produce motor outputs disallows the creation of coherent sensory maps, presumably because the spontaneous motor programs activate sets of muscles that cause corresponding sets of sensory receptors to be co-activated. At a coarse level, if you move your arm, it might run into something and now the parts of your arm that are near each other get to make coherent sensory input. Cells that fire together, wire together and a somatotopic sensory map is born.

So I think you can see the analogy I am imagining. Since the fine motor control output in KE family members is dysfunctional, the fine sensory perceptions that motor control should map to are also disturbed. I suppose this is one way that a developmental defect that leads to a specific motor problem could affect perception of language as well. Thinking this way would probably still require some sort of magic trick where the sensory patterning fails fairly deep in the hierarchy of language perception processing.

I wanted to make sure I was right about the motor dispute, so I pulled out the latest review. No discussion of intrinsic oscillations and language development, but in case y'all want an update here are some key areas researchers are focusing on:

1) Finding other natural mutations in the FOXP2 gene that lead to a phenotype similar to the original KE family.

2) Using Chromatin-Immunoprecipitation Chip (ChIP-Chip, I dread when they come up with a version of this specifically for our primate cousins) to discover molecular targets downstream of FOXP2. FOXP2 is a transcription factor, which means it binds to DNA. ChIP-Chip allows you to lock the FOXP2 onto whatever DNA it is associated with at the moment, pull those specific pieces of DNA out of solution, and see which pieces of DNA you pulled out by seeing if they stick to other chunks of DNA of which you know the identity.

3) Pursuing the observation that FOXP2 is actively regulated (they make more or less of the protein) during different types of vocal behavior in birds.

4) Pursuing the recent discovery that mice make ultrasonic vocalizations. If we can draw clear analogies between these vocalizations and birdsong or language then we can bring to bear the full arsenal of transgenic manipulations available in the mouse model.

Maybe this review was biased towards certain a certain approach, but I'm not seeing much here in terms of further characterizing the developmental phenotype associated with FOXP2 mutations. Is it not ethical or something? Did the KE family stop breeding? I think it might be worth taking a look at their very early EEGs. Finding a network-level signature for the disorder could provide an intermediate level phenotype and obviate the need to justify analogies between birdsong, mouse vocalizations, and human speech.


Bailey vs. Ann Althouse   posted by Razib @ 12/29/2006 07:55:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Ron Bailey and Ann Althouse get into it over the Frank-Meyer-is-racist-issue. Virginia Postrel defends Ron. No one who reads this blog will be surprised with my general sympathy for Ron in this matter, in part because I agree with his analysis on the merits (even removing the new data he brings to the table), and in part because there is a non-trivial overlap in our political worldviews. That being said, I don't want to make Ann into the devil, my main exposure to her is via Bloggingheads.TV, and she seems like a nice enough person. I empathize with her discomfort in the various political camps which have coalesced on the American scene. Since Ann is a law professor at the University of Wisconsin I don't doubt that she has some g-mojo. Nevertheless, my own impression of Ann is that she is somewhat thin in her exposure to various flavors of the American ideological spectrum (e.g., her general pose is the heterodox "right-winger" among ultra-Liberals). At one point in this Bloggingheads.TV dialogue with Jim Pinkerton Ann confronts the fact that Jim was an Iraq War Skeptic from a Right-realist perspective (I would point you to a segment, but I don't recall with confidence which one!). That such beasts exist seem to be clearly something of a surprise to her from what I could tell by her facial expression (ironic, considering her own heterodox posturing). Ann's own experience had conditioned her to simply connect anti-War sentiment with Leftism, and here she found herself faced with a reality-based conservative. This was not a critique of the Iraq War in language she understood, that is, the lexicon of social justice and utopian idealism, it was a hard-headed and cynical take on the Darwinian competition between nations and the right and wrong choices which emerge out of the utilitarian calculus.

What I'm trying to say is that Ann Althouse has a finite set of mental schemas. As an A-list blogger and Iraq War hawk who is generally socially liberal without the Maoist Puritanism (e.g., she isn't an ideological feminist) she is preloaded for a particular sort of discourse based on a particular range of common assumptions and disjunctions. A mild paleo-conservative like Jim Pinkerton is a species which Ann doesn't have any defenses or offenses against, and so their "discussion" was somewhat like watching two ships pass in the night. I am bringing this all up because I think Ann was faced with the same issues at the Liberty Conference. I've been to CATO events. There are a wide range of characters, and I mean characters, who show up, from fat cat oil speculators to mainstream journalists to the libertarian math professor from a fundamentalist college. You get all sorts of oddballs as you shift several deviations away from the norm in the American political spectrum, and various questions normally not entertained are now fair game. Again, I suspect Ann was operating in a domain where her mental schemas were ill-fitted, and she obviously couldn't get her bearings. Not only was she not steeped in the abstruse intellectual history of the American political Right before 1964, when conservatives, whether traditionalists like Russell Kirk or libertarians such as Frank Meyer, were in the wilderness and excluded from access to the establishment, but I also suspect that the sea of peculiar background assumptions common to "professional libertarians" was simply lost on her. Discussions about the right to discriminate may seem very bizarre, immoral even, when extracted outside of the context of a matrix of assumptions about liberty, justice and freedom, in other words, what makes the Good Society. Ann might have seen naked dispassion and a cruel lack of historical sensibility, but I suspect that her unfamiliarity with the libertarian subculture, its working assumptions, rendered the debates even more other-worldly than they should have been.

Which leaves me to the final point which I want to reiterate, and that is the role of intellectuals in transgressing manners and mores of society. Humans are social creatures and we are bound by particular conventions, whether it be cultural or biologically informed (or, more usually a synthesis). Men walking around with their penises hanging out of their pants in public would be problematic even though a penis is just a collection of atoms. Nevertheless, in the context of modern performance art it is perhaps more understandable. Whatever you think of art, for most humans the goals of inducing awe, exhibiting virtuosity, or shocking and disgusting, are easily attained. Many artists are good at what they do. But I hold that intellectuals, those who peddel ideas, should be no different in the proper context. We should go where conventional society does not go, explore, entertain, and discuss ideas which are not conventionally discussed. GNXP has done quite a bit of that over the years, and I myself am known personally to many of my friends as the sort that causes a collective dropping of the jaws becaues of a flip assertion or question. This does not mean that intellectual discourse is proper for normal social intercourse, but, I think it has a role to play in modern post-Enlightenment societies. Though Descartes was a Roman Catholic, he entertained the possibility of the non-existence of God (only to later to "prove" His existence). This was blasphemy to many contemporaries, but I believe that Descartes is the archetype of the modern intellectual, taking logic where normal reason dictates that you stop.

As I noted before I believe emotion plays a role in human affairs, and am willing to grant that it is the ends of life. That being said, just as normal social interaction is bounded by a modicum of custom, manners and etiquette, so intellectual discourse must be characterized by emotional detachment for it to truly be effective. Emotions are a powerful tool. When you see another human cry you feel for them, you empathize, and they are humanized. All of a sudden the dance with ideas seems less important and we are brought back to normal convential sociality. Anger, happiness, all these are the ends of life, but they are also tools and weapons of interpersonal manipulation. Ron recounts that Ann broke down and cried at one point. This to me is the real "money shot," I've made people cry or break down myself because of the questions I asked and where I went. It happens. But if you fancy yourself someone of some intellectual daring, you must go where the conventional do not dare, where they cannot. Someone has to.

Of course a meeting of libertarians is bounded by their own rules and bounds of discourse. But when you go into the house of a neighbor with whom you are not familiar you need to be careful to respect their ways and habits even if you are shocked and appalled (barring abominations like child sacrifice!). Many libertarians don't live in reality, they aren't grounded, and their fantasies of the minimal state are more of a "Secondary World" than Middle Earth ever was, but, they have a role to play in the ecology of ideas. The fact that they exist, and that they are who they are, is no crime against humanity.

I've posted on this topic more than once in part because it offers us lessons for this blog "community." It is certainly bounded by rules and conventions, but it is pretty diverse in its own way. The main lesson is that if things posted by the authors of this weblog (not in the comment boxes!) make you want to cry you might withdraw and find some place more congenial. Questions of how the world should be are important, Liberty Conferences are part of the universe, but here I would rather focus on how the world is.

(now you hot ones can go back to your science fiction)


"Western ideals" of beauty look to the South   posted by agnostic @ 12/29/2006 11:29:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Following a recent suggestion, I was just checking out the Lacey Chabert spread at Maxim's website, where I noticed a hottie ranking of theirs called 2006 Hot 100. Granted, individuals may quibble with aspects of the ranking, but it is presumably the product of many minds with diverse tastes in female appearance, so it's objective enough to get a rough idea of what young American guys find attractive. There is a bias toward current "it" girls, but I doubt the racial variation would be changed much if we looked at "it" girls from five years ago. And because Maxim panders to the lowest common denominator of male interests, it would have to be suicidal to feature a significantly lower proportion of women of a certain appearance if red-blooded males truly desired to oogle women of that appearance (e.g., if it featured few blondes when the average potential reader was blonde-crazy). We can thus test whether the ranking actively glorifies or passively reflects a desire for Nordic features, whose hegemony is a common canard in discussions about standards of beauty and ethnic variation in appearance.

Top 10 by hair color and race below the fold:

10 Christina Milian. Brunette. Cuban.
9 Keira Knightley. Brunette. Scottish, Irish, English.
8 Kate Bosworth. Brunette. English?
7 Cameron Diaz. Blonde. Cuban, English, German, Cherokee.
6 Scarlett Johansson. Blonde. Ashkenazi Jewish, Danish.
5 Stacy Keibler. Blonde. German?
4 Angelina Jolie. Brunette. French, Iroquois, Czech.
3 Lindsay Lohan. Auburn. Italian, Irish.
2 Jessica Alba. Brunette. Mexican, Danish, French.
1 Eva Longoria. Brunette. Mexican.

If Nordic looks reigned supreme, we should expect to see more blondes than 3 of 10, which appears at or below expectation for a majority Northern European country, judging by the graphic at the Wikipedia entry on hair color. On an absolute level, there's no shortage of blondes, so if the media devils really wanted push the "blondes are more beautiful" idea, they could've easily packed the top 10 with them. The racial backgrounds underrepresent the average Northern European phenotype: since Keira Knightley and Lindsay Lohan have the "Black Scottish / Irish" look, that leaves just Stacy Keibler, Kate Bosworth, and Scarlett Johansson who look Nordic.

Turning to the entire 100 (go to the bottom for more detail on the following numbers), those of African and East Asian descent are not well represented. In fact, only 2 of 100 are East Asian, and they rank very low. That's at expectation, since Americans of Korean, Chinese, and Japanese descent make up 2.1% of the population. Vanessa Minnillo ranks highly at 15, but she's mixed Filipina / Pacific Islander and Irish-Italian, not East Asian. Overall, 3 of 100 are African-American. This is quite below their percentage of 13.7% in the general population, and none score very highly. Finally, 9 of 100 have partial African or East Asian ancestry, and they are fairly evenly distributed in the ranking from 90 to 22.

Latin Americans, though, do pretty well. I make no claim about what their neutral markers would tell us about the individuals' racial backgrounds, and I therefore included a couple "half"-Latin Americans for the same reason I included "full" Latin Americans. The point is simply to show how a mixed-race, decidedly non-Nordic group does. There are 14 of 100 who are Latin American (including Daniella Alonso, who I also put in the "part-East Asian" group), which appears at expectation since Hispanics make up 14.1% of the US population as of 2004. However, the Hispanic population surged in the US in the wake of the 1986 amnesty, and since the women in the ranking are mostly in their 20s or older, the Hispanic percentage among their age group is surely lower than 14.1%. So, Hispanics are likely somewhat overrepresented. Furthermore, the lowest-ranking Hispanic clocks in at 71, and 4 of the top 10 are Hispanic, including 1 and 2. The strong performance of Latin Americans in international beauty pageants is nothing new, so one wonders why the Nordic hegemony idea has persisted into the second half of the 20th C. (In this respect, it is like the idea that the WASPs are keeping the Sicilians and Semites under their golf cleat -- perhaps true awhile ago, but clearly false for decades.)

The numbers:

East Asians

98 Yunjin Kim
93 Grace Park

African-Americans

82 Vanessa Simmons
77 Ciara
43 Gabrielle Union

Interracials of African or E.Asian background

90 Chilli (1/2 Af-Am, 1/2 East Indian)
88 Tila Tequila (3/4 Vietnamese, 1/4 French)
84 Amerie (1/2 Af-Am, 1/2 Korean)
79 Halle Berry (1/2 Af-Am, 1/2 English)
53 Moon Bloodgood (Korean, Irish, Dutch)
45 Beyonce (1/2 Af-Am, 1/2 Louisiana Creole)
41 Daniella Alonso (1/2 Puerto Rican, 1/2 Japanese-Peruvian)
40 Alicia Keys (1/2 Irish-Italian, 1/2 Jamaican)
22 Mariah Carey (1/2 Afro-Venezuelan, 1/2 Irish)

Hispanics

71 Roselyn Sanchez
68 Cinthia Moura
60 Shakira
59 Jordana Brewster
55 Vanessa Marcil
41 Daniella Alonso
39 Nadine Velazquez
27 Eva Mendes
19 Jamie-Lynn Sigler
16 Christina Aguilera
10 Christina Milian
7 Cameron Diaz
2 Jessica Alba
1 Eva Longoria

From the archives: see here & links therein.
Update: changed the info on Chilli, Beyonce, and Vanessa Minnillo.



Ali on the radio   posted by Razib @ 12/29/2006 10:58:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Blogger Ali Eteraz will be on the radio 4:30 PM today PDT (check link for webfeed).

Thursday, December 28, 2006

DevIntel at SB   posted by amnestic @ 12/28/2006 11:58:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Chris Chatham has moved on over to Seed's megasite finally. You could do a lot worse than reading his entries and the discussion he inspires. Here's some on the potential for enhancing working memory with dopamine system manipulations.


Rome vs. Assyria   posted by Razib @ 12/28/2006 11:25:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

SharpBlue on Rome vs. Assyria. Interesting fact, the last great Assyrian king, Ashurbanipal, could read and write (remember, this is before widespread use of phonetic script, so this was no mean feat). Thanks to Ashurbanipal's library much of the corpus of Sumerian and Akkadian literature came down to us.


YouTube Open Thread   posted by Razib @ 12/28/2006 08:27:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Post YouTube's that you think are really interesting to GNXP readers in the comments.


Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates   posted by Razib @ 12/28/2006 07:55:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates:
Our analyses of the rates of protein evolution in these species suggest that genes expressed in the human brain have in fact slowed down in their evolution since the split between human and chimpanzee, contrary to some previously published reports. We suggest that advanced brains are driven primarily by the increasing complexity in the network of gene interactions. As a result, brain-expressed genes are constrained in their sequence evolution, although their expression levels may change rapidly.


...we've always told you that "gene expression" is where it's at :) It's PLOS, so go read the whole thing for free.


PS3 vs. WII   posted by Razib @ 12/28/2006 01:04:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

I stopped playing video games when I was 16. So I don't get a lot of the references of the below comparison... (guess which one likes science fiction)

[below the fold for after work]



Wednesday, December 27, 2006

Althouse is wrong, Goldberg is right   posted by Razib @ 12/27/2006 11:39:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

On this bloggingheads.tv segment Ann Althouse rips Jonah Goldberg for his quasi-defense of a discussion of the ideas and influence of Frank Meyer, the libertarian conservative who was the father of "fusionism" and arguably the man behind William F. Buckley's throne. Althouse was appalled that at a Liberty Fund event to which she was invited a discussion of the great man's ideas did not dwell long enough upon his support for the American South's practice of Jim Crow in the name of State's Rights (perhaps one might say that Southerners supported State's Rights because of Jim Crow, while Meyer accepted Jim Crow because of State's Rights). Althouse's point, from what I can gather, is that Oh my god Frank Meyer was a racist!!!! Goldberg made, I thought, a pretty level-headed response, sometimes one must extract and abstract ideas from their context to explore fully their ramificatins, validity and utility. This does not mean that I don't share Althouse's discomfort, even censure, of Jim Crow and the Right's support of these policies during the 1950s and 1960s. The Zeitgeist has changed, and for the better. Especially for those like myself who happen to have brown skin. Nevertheless, there are two issues that we must address

1) Ideas are not like a stew, each and every one mixed together so that they are fundamentally inseparable, unperceivable without tasting the whole.

2) To examine questions from every angle one must withold judgement, censure or outrage on occasion.

This does not negate emotion, feeling or values. It simply means that different aspects of life, and cognition, have their own purposes. Margaret Sanger was a progressive racialist eugenicist. That doesn't mean that Planned Parenthood is Nazi. Isaac Newton was an alchemical nut. That doesn't mean that his Mechanics and Optics don't exhibit a scientific virtuosity which induces awe. Emotions tell us what is important. Rationality allows us to realize and perpetuate what is important.


The nose knows   posted by p-ter @ 12/27/2006 11:57:00 AM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

The paper on the ability of humans to track smells contained a couple interesting references on the human specific loss of some olfactory genes (see an old post here for an interesting correlation between the loss of these genes and the rise of color vision). Apparently, some genes have both functional and non-functional versions that still segregate within the population. So do different populations have receptors for different scents?

The last link is to a paper that typed 51 olfactory receptor genes in 189 people. It's a little unclear where these 189 people come from (though they do refer to African-Americans, so it's apparently a sample of Americans); it would be interesting to type them in a large number of populations (the human diversity panel, perhaps?) and give that hypothesis a whirl.

However, see this paper for an argument that humans actually have a pretty good sense of smell, and some possible explanations for why the loss of olfactory receptors doesn't mean the loss of the sense:
[M]uch of the olfactory system can be removed with no effect on smell perception. The olfactory receptor genes map topographically onto the first relay station, a sheet of modules called glomeruli in the olfactory bulb. Up to 80% of the glomerular layer in the rat can be removed without significant effect on olfactory detection and discrimination. If the remaining 20% of the glomeruli-and the olfactory receptor genes they represent-can subserve the functions of 1,100 genes, it implies that 350 genes in the human are more than enough to smell as well as a mouse.

Tuesday, December 26, 2006

The smell of victory   posted by p-ter @ 12/26/2006 07:20:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

Humans can track smells, and the ability to do so is greatly aided by practice (and the use of both nostrils). Very cool:
Whether mammalian scent-tracking is aided by inter-nostril comparisons is unknown. We assessed this in humans and found that (i) humans can scent-track, (ii) they improve with practice, (iii) the human nostrils sample spatially distinct regions separated by approx3.5 cm and, critically, (iv) scent-tracking is aided by inter-nostril comparisons. These findings reveal fundamental mechanisms of scent-tracking and suggest that the poor reputation of human olfaction may reflect, in part, behavioral demands rather than ultimate abilities.


Evangelical Atheists and the Sciences of Religion   posted by Matoko Kusanagi @ 12/26/2006 07:04:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

I spent some time with the Edge Reality Club today. I hadn't had time to read it yet. It is no surprise to me that Scott Atran is closest to me ideology and analysis. I liked his book far better than any of Harris', Dawkins', and Dennett's books I've read.
The topic of the discussion was Beyond Belief: Science, Religion, Reason and Survival.


The other participants accused Atran of ignoring the fact that religions, and in particular, Islam, actively encourage destructive behavior like suicide bombing, apostate killing, pograms, etc. I dont think he ignores that at all. But he says instead, what can we do with what we know? Im so grateful to find someone who thinks about this the way I do. This is exactly what I mean, when I talk about leveraging Islam to stop the slaughter and help instantiate democracy in Iraq.
Atran on evangelical atheism:
At the conference, Harris and partners ignored the increasingly rich body of scientific research on religion. They ignored the vast body of empirical data and analysis of terrorism — a phenomenon they presented as a natural outgrowth of religion. The avowedly certain but uncritical arguments they made about the moral power of science and the moral bankruptcy of religion involved no science at all. Some good scientists stepped out of their field of expertise, leaving science behind for the unreflective sort of faith-based thinking they railed against. Sadly, in this regard, even good scientists join other people in unreason.

Harris despairs that my approach to dogmatism is to throw up my hands and "make declarations about ‘the basic irrationality of human life and society'." No, I argue that one way to deal with this important problem is to use science and rational processes to study irrational ones and then to leverage that scientific knowledge in ways that can affect public policy, although this second step may have to be more art than science. Harris suggests that if, indeed, irrationality is some vestige of our evolutionary legacy, then we should still be able to master it and perhaps eventually eliminate it from society through reason and vigilance as we are increasingly able to do with rape. I think a better, deeper, more pervasive analogy would be sex: repress it one way and it will pop out other ways.
My critique of Harris and company was that:

(1) An increasing body of scientific research on religion suggests that, contrary to Harris's personal and scientifically uninformed intuitions about what religion consists of, the apparent invalidity of religious thought is insensitive to the kind of simple-minded disconfirmation through demonstrations of incoherence that Harris and others propose.

(2) No data by Harris or others was offered to suggest that the naturalistic worldview they mean to replace religion with would be, or could be, successful; or that such a worldview would generate more happiness, compassion or peace (which most us at the conference hope for).

(3) Evidence supporting empirical claims about negative behavior caused by religious beliefs in general, or Islam in particular, was based on a decidedly selective sample or idiosyncratic interpretation (e.g., Harris tells us that he has read the Qur'an and on his reading, which he may share with some minority of Muslims, the Qur'an literally prescribes, or at least sanctions, suicide terrorism).

(4) Experiments on "sacred values" (which Harris refers to in his reply but misunderstands, and which were presented in more rigorous form before the American Association for the Advancement of Science and the National Security Council at the White House) suggest that arguments by Harris and others about how to best lessen the noxious effects of dogmatism are liable to do more harm than good for his own cause (which is also my own cause and that of most others at the conference).

Now, according to Salam's colleague and co-Nobel Prize winner Steven Weinberg, scientists must rise up to the challenge of liberating humanity from "the long nightmare of religion. " Biologist Richard Dawkins tells us that we need to "come out of the closet" and form a political lobby of committed atheists and scientists to do public battle with religion and other forms of "rubbish" that tyrannize the mind. For neuropsychology student Sam Harris, technological advances in the ability to terrorize and wage war require an uncompromising and unrelenting intellectual struggle to destroy religion — especially, but not exclusively, Islam — and banish unreason beyond the pale of civilization.
I find it fascinating that among the brilliant scientists and philosophers at the conference, there was no convincing evidence presented that they know how to deal with the basic irrationality of human life and society other than to insist against all reason and evidence that things ought to be rational and evidence based. It makes me embarrassed to be a scientist and atheist. There is no historical evidence whatsoever that scientists have a keener or deeper appreciation than religious people of how to deal with personal or moral problems. Some scientists have some good and helpful insights into human beings' existential problems some of the time, but some good scientists have done more to harm others than most people are remotely capable of.

Scott and I are in complete agreement--sho, supernatural and religious beliefs cause dreadful problems. BUT it is biologically, culturally, and psychologically impossible to destroy religion.
What to do? Since we cannot eradicate religion, let's leverage it instead, for benevolent goals.

Here I quote Atran's section on sacred values, and how those values can leverage arbitration and conflict resolution in the face of anti-rational behavior. The classic example of anti-rational behavior is the Palestine/Israel conflict.
Sacred Values And Bounds On Rational Resolution Of Conflict. Dan Dennett seems to argue that because most people are rational most of time, as in properly navigating when crossing the street, then people should be perfectly capable of following and accepting rational arguments against religion if only the repressive social and political support for religion could be jettisoned. Now, unlike in the field of economic judgment and decision making, where basic assumptions of rationality have been scientifically sundered (most prominently by recent Nobel laureates Danny Kahneman and Thomas Schelling), there has been little serious of study of the scope and limits of standard notions of rationality in moral judgment and decision making. There is, however, some evidence that rationality is not standard for religion and morality.

Religious behavior often seems to be motivated by sacred values, that is, values which a moral community treats as possessing transcendental significance that underlies cultural identity and precludes comparisons or tradeoffs with material or instrumental values of realpolitik or the marketplace. As Immanuel Kant framed it, virtuous religious behavior is its own reward and attempts to base it on utility nullifies its moral worth. Instrumental decision-making (or "rational choice") involves strict cost-benefit calculations regarding goals, and entails abandoning or adjusting goals if costs for realizing them are too high. A sacred value is a value that incorporates moral and ethical beliefs independently of, or all out of proportion to, its prospect of success."

Current approaches to resolving resource conflicts or countering political violence assume that adversaries make instrumentally rational choices. However adversaries in violent political conflicts often conceptualize the issues under dispute as sacred values, such as when groups of people transform land from a simple resource into a "holy site" to which they may have non-instrumental moral commitments. Nowhere is this issue more pressing than in the Israeli-Palestinian dispute, which the majority of people in almost every country surveyed (e.g., in the June 2006 Pew Global Attitudes Survey) consistently view as the greatest danger to world peace. Our research team − including psychologists Jeremy Ginges and Douglas Medin, and political scientist Khalil Shikaki − conducted studies indicating that instrumental approaches to resolving political disputes are suboptimal when protagonists transform the issues or resources under dispute into sacred values. We found that emotional outrage and support for violent opposition to compromise over sacred values is (a) is not mitigated by offering material incentives to compromise but (b) is decreased when the adversary makes materially irrelevant compromises over their own sacred values.

In a survey of Jewish Israelis living in the West Bank and Gaza (settlers, N = 601) conducted in August 2005, days before Israel's withdrawal from Gaza, we randomly presented participants with one of several hypothetical peace deals. All involved Israeli withdrawal from 99% of the West Bank and Gaza in exchange for peace. We identified a subset of participants (46%) who had transformed land into an essential value; they believed that it was never permissible for the Jewish people to "give up" part of the "Land of Israel" no matter how extreme the circumstance. For these participants, all deals thus involved a "taboo" trade-off. Some deals involved an added instrumental incentive, such as money or the promise of a life free of violence ("taboo+"), while in other deals Palestinians also made a "taboo" trade-off over one of their own sacred values in a manner that neither added instrumental value to Israel nor detracted from the taboo nature of the deal being considered ("tragic"). From a rational perspective, the taboo+ deal is improved relative to the taboo deal and thus violent opposition to the tragic deal should be weaker. However, we observed the following order of support for violence: taboo+ > taboo > tragic; where those evaluating the tragic deal showed less support for violent opposition than the other two conditions. An analysis of intensity of emotional outrage again found that taboo+ > taboo > tragic; those evaluating the tragic deal were least likely to report anger or disgust at the prospect of the deal being signed.

These results were replicated in a survey of Palestinian refugees (N=535) in Gaza and the West Bank conducted in late December 2005, one month before Hamas was elected to power. In this experiment, hypothetical peace deals (see supporting online materials) all violated the Palestinian "right of return", a key issue in the conflict. For the 80% of participants who believed this was an essential value, we once more observed that for violent opposition the order between conditions was taboo+ > taboo > tragic, where those evaluating a "tragic" deal showed lowest support for violent opposition. The same order was found for two measures ostensibly unrelated to the experiment: (a) the belief that Islam condones suicide attacks; and (b) reports of joy at hearing of a suicide attack (there is neuroimaging evidence for joy as a correlate of revenge). Compared to refugees who had earlier evaluated a taboo or taboo+ deal, those who had evaluated a tragic deal believed less that Islam condoned suicide attacks; and were less likely to report feeling of joy at hearing of a suicide attack. In neither the settler nor the refugee studies did participants responding to the "tragic" deals regard these deals as more materially likely or implementable than participants evaluating taboo or taboo+ deals.

These experiments reveal that in political disputes where sources of conflict are cultural, such as the Israeli-Palestinian conflict or emerging clashes between the Muslim and Judeo-Christian world, attempts to lessen violent opposition to compromise solutions can backfire by insisting on instrumentally-driven tradeoffs and rational choices, while non-instrumental symbolic compromises may reduce support for violence. Further studies with 750 Hamas members and non Hamas controls this past June, show similar results, as do on-going pilot studies among Christian fundamentalists who consider abortion and gay marriage to violate sacred values.

Given these facts, I and others have been assisting in political negotiations that target recognition of sacred values over instrumentally rational tradeoffs. The goal is to break longstanding deadlocks that have proven immune to traditional business-like frameworks for political negotiation that focus on rational choices and tradeoffs. By targeting "sacred values" and "moral obligations" I don't seek to "ignore the role of religion" in people's actions and decisions, though Harris complains this is the reason I introduce sacred values into the discussion. My aim is quite the opposite: to politically engage those deepest held religious beliefs that are matters of life and death for peoples and nations.


This is what I mean when I talk about using the science of religion to solve resistant geo-political conflicts. Like Palestine. Like Iraq. If we understand the mechanism, can't we exploit it?

note: The "sciences of religion" is a tribute to one of my favorite books of Islamic theo-philosophy, the incomparable al-Ghazali's The Resusitator of the Sciences of Religion.


ASPM and flagella   posted by p-ter @ 12/26/2006 04:40:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

In the profile of Bruce Lahn in Science, the following quote, on the possibility that the selective pressure on ASPM could be due to sperm function, stood out to me:
But genome researcher Chris Ponting of the University of Oxford, U.K., notes that microcephalin and ASPM are also expressed outside the brain. In last May's issue of Bioinformatics, he reported that part of ASPM's DNA sequence resembles that of genes involved in the function of flagella, which propel sperm. Earlier work had shown that ASPM is expressed during sperm production. Ponting suggests that natural selection might have acted on flagellar function rather than brain growth.
This would be a striking result, if true. However, I'm skeptical (actually, I'll put the punchline right here: the data provide little, if any, support for this). Let's review:

Ponting's paper is a look at the sequence of the ASPM gene-- it's possible, with this data, to determine the eventual sequence of the protein and see if any regions of the protein ("domains", we call them) are similar to parts of other proteins. If those other proteins have a known function, you might infer that ASPM has a similar function. And indeed, ASPM shares a domain, called ASH, in common with some other proteins. The function of that domain? Well, it's not clear, but as Pontig writes, "[t]hese domains are present in proteins associated with cilia, flagella, the centrosome and the Golgi complex".

This is all well and good, but to jump from a protein possibly "associated with cilia, flagella, the centrosome and the Golgi complex" to saying the selective pressure on the gene is due to flagellar function in sperm is a serious leap indeed. Where does this come from?

Frankly, I have no idea; perhaps I'm missing a key part of the puzzle. But another paper used actual molecular tecniques to look at the distribution of ASPM in neural stem cells. In their words, "Aspm was found to be concentrated at mitotic spindle poles". And what else is found at mitotic spindle poles? Centrosomes, of course, one of the possible locations for ASPM as determined by Pontig. As other centrosomal proteins are known to be involved in brain size, this is perfectly in line with the hypothesis that ASPM is a regulator of brain growth.

I'm not man enough to say the selective pressure on ASPM is definitely not due to a flagellar role in sperm, but for the moment, I ain't buyin' it.

Monday, December 25, 2006

Human monogamy is a farce!   posted by Matt @ 12/25/2006 11:27:00 PM
StumbleUpon Toolbar Digg Reddit Del.icio.us Ma.gnolia Newsvine

EDIT: I just found a paper (posted here)estimating the rate of human EPC to be between <1%-30% with a median of 3.7%. In other words, 1 in 25 fathers reading this are raising children that are the product of their partners infidelity...


In a previous post (link) the bold claim was made that there is no biological predisposition towards human monogamy, but instead what drives us toward monogamy-like mating system is culture. There seem to be several independent lines of evidence that supports my position.

  1. Anecdotal evidence. How many of us:
    1. Have never had a friend who cheated?
    2. Cheated ourselves?
    3. Know somebody who was actually cuckolded?
  2. Evidence from parsimony-
    1. There are 5,419 mammal species listed in Mammal Species of the World, the definitive resource. Of these, less than 5% are monogamous. Which is more parsimonious- that we ARE or ARE NOT monogamous?
    2. None of the great apes, our closest living related species, are monogamous
  3. Evidence from the literature.
    1. anybody have some good examples of data that defines human genetic mating system?