Substack cometh, and lo it is good. (Pricing)

mtDNA, fair game or folly?

RPM and Kambiz comment on a paper which argues for the utility of mtDNA in phylogeography.
Remember,

  • there is lots of mtDNA that is easy to extract because there are so many mitochondria within eukaryotic cells
  • it mutates fast, building up a lot of genetic variation, in a neutral matter (i.e., perfect “clock”)
  • it is uniparental, passed from mother to daughter, making the coalescent model congenially tractable
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