H. Allen Orr (one of the authors of the study I mentioned recently) has a fun article in Scientific American on testing hypotheses about natural selection using genetic data. Orr has been one of the few people to try and formally model adaptation in a population genetics framework (I highly recommend this review article from 2005 for a well-written and accessible discussion of this issue), so his thoughts are worth a read.
And if you’re in the mood for a chuckle, check out Larry Moran’s thoughts on the article.
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