

The differences don’t invalidate the robustness of admixture analyses. It’s just that these results are always carved around the joints and reifications which are human-digestible, and humans are the ones who pick the specific parameter values and data inputs around which the models are constructed. The companies have different reference populations, and these reference populations are the data inputs around which individuals are constructed as linear combinations. 23andMe uses a sophisticated system that looks at haplotype blocks, but it seems quite clear that finely admixed people are sometimes difficult for them to resolve (because of the uniqueness of their blocks in comparison to their reference populations).


Comments are closed.